Lagnaoui Rajaa, Moore Nicholas, Moride Yola, Miremont-Salamé Ghada, Bégaud Bernard
Département de Pharmacologie, Université Victor Segalen, Bordeaux, France.
Pharmacoepidemiol Drug Saf. 2003 Sep;12(6):511-5. doi: 10.1002/pds.853.
Benzodiazepines (BZD) are commonly prescribed in the elderly. Persons with dementia may be at a greater risk of adverse reactions of BZD such as cognitive impairment.
To assess the prevalence of BZD use in Alzheimer's disease patients and to examine patient and drug-characteristics associated with this use.
Cross-sectional study.
Five thousand community-dwelling and institutionalized patients initiating a treatment with tacrine for a mild to moderate Alzheimer's disease and included in the tacrine-study (Paco cohort).
Patient characteristics and BZD use recorded at the inclusion.
Use of BZD during the 3 months prior to inclusion.
The 3-month prevalence of ever use of BZD was 20%. After controlling for age and gender, there was a non-significant inverse association between BZD use and a score of Mini-Mental Status Evaluation (MMSE) below 24 (OR: 0.88, 95% CI: 0.71-1.09), and significant inverse association with an increased number of chronic conditions (OR: 0.73, 95% CI: 0.58-0.91). Higher use of BZD was associated with higher level of overall drug consumption (OR: 2.3, 95% CI: 1.97-2.80).
Alzheimer's disease patients are frequently prescribed BZD. A low score of MMSE (< 24) is associated with a decreased use of BZD. These results suggest important differences in BZD use patterns among persons with Alzheimer's disease.
苯二氮䓬类药物（BZD）在老年人中常用。痴呆患者使用BZD出现认知障碍等不良反应的风险可能更高。
评估阿尔茨海默病患者使用BZD的患病率，并研究与此使用相关的患者和药物特征。
横断面研究。
5000名社区居住和机构居住的患者，开始用他克林治疗轻度至中度阿尔茨海默病，并纳入他克林研究（Paco队列）。
纳入时记录的患者特征和BZD使用情况。
纳入前3个月内BZD的使用情况。
曾使用BZD的3个月患病率为20%。在控制年龄和性别后，BZD使用与简易精神状态检查表（MMSE）评分低于24分之间存在无显著统计学意义的负相关（比值比：0.88，95%可信区间：0.71 - 1.09），与慢性病数量增加存在显著负相关（比值比：0.73，95%可信区间：0.58 - 0.91）。BZD使用量较高与总体药物消费量较高相关（比值比：2.3，95%可信区间：1.97 - 2.80）。
阿尔茨海默病患者经常被处方使用BZD。MMSE评分低（< 24）与BZD使用减少有关。这些结果表明阿尔茨海默病患者在BZD使用模式上存在重要差异。
