Bulkowstein Mordechai, Mordish Yair, Zimmerman Deena R, Sherman Eliezer, Berkovitch Matitiahu
Clinical Pharmacology and Toxicology Unit, Drug Consultation Center, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel-Aviv University.
Vet Hum Toxicol. 2003 Oct;45(5):239-40.
A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away within 24 h. Few days later, the patient used another 200 mg ketoconazole tablet, and within an hour experienced a similar clinical picture, which resolved again spontaneously within hours. Laboratory evaluations, including head CT scan, were normal. This case illustrates the need for close vigilance in adverse drug reactions, particularly in the elderly.
一名77岁患者在首次服用200毫克酮康唑1小时后出现肢体无力、腿部麻痹、构音障碍和震颤。所有不适在24小时内消失。几天后，该患者又服用了一片200毫克的酮康唑，1小时内出现了类似的临床表现，数小时后又自行缓解。包括头部CT扫描在内的实验室检查均正常。该病例表明，对于药物不良反应，尤其是老年患者，需要密切监测。
