Petroianu Georg A, Hasan Mohd Y, Kosanovic Melita, Vijayasarathy C, Saleh A M
Department of Pharmacology & Therapeutics, UAE University, PO Box 17666 Al-Ain, United Arab Emirates.
Vet Hum Toxicol. 2003 Oct;45(5):251-3.
This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group 1 received 100 nM POX, Group 2 received 50 microM MCP. Group 3 received 100 nM POX + 50 microM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.
本研究通过红细胞乙酰胆碱酯酶（RBC-AChE）活性评估了苯甲酰胺化合物甲氧氯普胺（MCP）对对氧磷（POX）抑制作用的保护效果。使用三组大鼠，每组6只。所有物质均每日腹腔注射给药，持续5天，随后休息2天。7天的周期重复6次。第1组接受100 nM POX，第2组接受50 μM MCP。第3组接受100 nM POX + 50 μM MCP。在基线时以及每个7天周期后进行红细胞乙酰胆碱酯酶测量。使用曼-惠特尼秩和检验比较酶活性。甲氧氯普胺在体内对POX抑制RBC-AChE具有显著的保护作用。
