血红蛋白雅基马（一种高氧亲和力血红蛋白）的放血疗法。

Venesection in haemoglobin Yakima, a high oxygen affinity haemoglobin.

作者信息

Grace R J, Gover P A, Treacher D F, Heard S E, Pearson T C

机构信息

Department of Haematology, St. Thomas' Hospital, London, UK.

出版信息

Clin Lab Haematol. 1992;14(3):195-9. doi: 10.1111/j.1365-2257.1992.tb00365.x.

DOI:10.1111/j.1365-2257.1992.tb00365.x

PMID:1451399

Abstract

High oxygen affinity haemoglobins result in polycythaemia and cardiovascular adaptation to maintain tissue oxygenation. The polycythaemia can cause symptoms of hyperviscosity and vaso-occlusive disease. We report a kindred with a high affinity haemoglobin (Haemoglobin Yakima) one of whose members gave birth to two infants with intra-uterine growth retardation and who suffered with symptoms of hyperviscosity which settled on reduction of the PCV by venesection.

摘要

高氧亲和力血红蛋白会导致红细胞增多症以及心血管适应性改变以维持组织氧合。红细胞增多症可引发高黏滞血症和血管闭塞性疾病的症状。我们报告了一个患有高亲和力血红蛋白（血红蛋白亚基马）的家族，该家族中有一名成员产下了两名宫内生长受限的婴儿，并且该成员患有高黏滞血症症状，通过静脉放血降低红细胞压积后症状得到缓解。