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控制性动脉低血压在内镜鼻窦手术中的应用

Application of controlled arterial hypotension in endoscopic rhinosurgery.

作者信息

Cincikas Darius, Ivaskevicius Juozas

机构信息

Vilnius Missionary Hospital, Subaciaus 26, 2600 Vilnius, Lithuania.

出版信息

Medicina (Kaunas). 2003;39(9):852-9.

Abstract

Intraoperative bleeding is one of the major problems in endoscopic surgery of sinuses. In the case of the expanded process, still more numerous interventions are performed with general anesthesia. The objective of research is to compare intraoperative hemorrhage and the visibility of the operative field during normotension and hypotension anesthesia caused by nitroglycerin and captopril when performing endoscopic operations of accessory nasal sinuses. Fifty-two patients of physical health state 1-2 according to ASA were examined: for 32 the controlled hypotension (Group H) was applied, 20 patients underwent operations in normotension (Group N). All patients on the eve of the operation were premedicated with diazepam; Group H patients on the day of operation received 6.25 mg of captopril. Anesthesia was carried out with fentanyl and halothane steam in the 50:50% mixture of oxygen and laughing gas. In Group H arterial blood pressure was lowered by nitroglycerin infusion. The average arterial blood pressure was maintained in GroupH within the limits of 50-60 mmHg. Hypotension was coordinated with the rising of the head-bed of the operating table at 5 degrees. Hemorrhage was measured by collecting blood with the pump graded with the precision of 25 ml. The visibility of the operative field was evaluated subjectively every 15 minutes according to the scale of 5 points proposed by Fromm. In both groups the average arterial blood pressure values as well as the values of the frequency of heart contractions differed statistically significantly. In the hypotensive group, hemorrhage during operation was less, on the average, (208 ml) than in Group N (349.2 ml). The visibility of the operative field was by one point, on the average, better than in Group H. No anesthetic complications were observed during investigation. In summary, it is possible to state that the controlled arterial hypotension caused by captopril and nitroglycerin reduced significantly intraoperative hemorrhage and improved the visibility of the operative field in endoscopic rhinosurgery.

摘要

术中出血是鼻窦内镜手术中的主要问题之一。在扩大手术过程中,更多的手术是在全身麻醉下进行的。本研究的目的是比较在进行副鼻窦内镜手术时,使用硝酸甘油和卡托普利引起的正常血压麻醉和低血压麻醉期间的术中出血情况以及手术视野的清晰度。对52例根据ASA身体健康状况为1 - 2级的患者进行了检查:32例采用控制性低血压(H组),20例患者在正常血压下进行手术(N组)。所有患者在手术前夕均用安定进行术前用药;H组患者在手术当天服用6.25毫克卡托普利。采用芬太尼和氟烷蒸汽在氧气和笑气按50:50%混合的情况下进行麻醉。在H组中,通过输注硝酸甘油降低动脉血压。H组的平均动脉血压维持在50 - 60 mmHg范围内。低血压与将手术台床头抬高5度相配合。通过用精度为25毫升的泵收集血液来测量出血量。根据弗洛姆提出的5分制量表,每15分钟主观评估一次手术视野的清晰度。两组的平均动脉血压值以及心率值在统计学上有显著差异。在低血压组,术中平均出血量(208毫升)比N组(349.2毫升)少。手术视野的清晰度平均比N组好一个等级。在研究过程中未观察到麻醉并发症。总之,可以说由卡托普利和硝酸甘油引起的控制性动脉低血压显著减少了内镜鼻窦手术中的术中出血,并改善了手术视野的清晰度。

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