Hirata Atsushi, Kasahara Masataka, Matsuura Nobuyuki, Ichinohe Tatsuya
Department of Dental Anesthesiology, Tokyo Dental College, Tokyo 101-0061, Japan.
Department of Pharmacology, Tokyo Dental College, Tokyo 101-0061, Japan.
J Vet Med Sci. 2018 Mar 2;80(2):354-360. doi: 10.1292/jvms.17-0319. Epub 2017 Dec 22.
The aim of this study was to investigate the effect of remifentanil infusion on oral tissue blood flow including submandibular gland tissue blood flow (SBF) and internal carotid artery blood flow (ICBF) in rabbits during sevoflurane anesthesia. Twelve male Japan White rabbits were anesthetized with sevoflurane and remifentanil. Remifentanil was infused at 0.2 and 0.4 µg/kg/min. Measurements included circulatory variables, common and external carotid artery blood flow (CCBF, ECBF), ICBF, tongue mucosal blood flow (TMBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue blood flow (BBF), tongue muscle tissue blood flow (TBF) and SBF. Vascular resistances for each tissue, including the tongue mucosa, masseter muscle, mandibular bone marrow, tongue muscle and submandibular gland, were calculated by dividing the mean arterial pressure by the respective tissue blood flow. Remifentanil infusion decreased oral tissue blood flow and circulatory variables. CCBF, ECBF and ICBF did not change. The calculated vascular resistance in each oral tissue, except for the tongue mucosa, increased in an infusion-rate-dependent manner. These results showed that remifentanil infusion reduced TMBF, MBF, BBF, TBF and SBF in an infusion-rate-dependent manner without affecting ICBF under sevoflurane anesthesia.
本研究的目的是探讨在七氟醚麻醉期间，输注瑞芬太尼对兔口腔组织血流的影响，包括颌下腺组织血流（SBF）和颈内动脉血流（ICBF）。12只雄性日本白兔接受七氟醚和瑞芬太尼麻醉。瑞芬太尼以0.2和0.4μg/kg/min的速度输注。测量指标包括循环变量、颈总动脉和颈外动脉血流（CCBF、ECBF）、ICBF、舌黏膜血流（TMBF）、咬肌组织血流（MBF）、下颌骨髓组织血流（BBF）、舌肌组织血流（TBF）和SBF。通过将平均动脉压除以相应组织血流来计算每个组织的血管阻力，包括舌黏膜、咬肌、下颌骨髓、舌肌和颌下腺。输注瑞芬太尼会降低口腔组织血流和循环变量。CCBF、ECBF和ICBF没有变化。除舌黏膜外，每个口腔组织计算出的血管阻力以输注速率依赖的方式增加。这些结果表明，在七氟醚麻醉下，输注瑞芬太尼以输注速率依赖的方式降低TMBF、MBF、BBF、TBF和SBF，而不影响ICBF。
