通过基质辅助激光解吸/电离飞行时间质谱监测优化肽的聚乙二醇化过程。 - Suppr

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超能文献

Optimization of the PEGylation process of a peptide by monitoring with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

作者信息

Na Dong Hee, Youn Yu Seok, Lee Kang Choon

出版信息

Rapid Commun Mass Spectrom. 2003;17(19):2241-4. doi: 10.1002/rcm.1175.

DOI:10.1002/rcm.1175

PMID:14515324

Abstract

摘要

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引用本文的文献

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PEGylation of octreotide: II. Effect of N-terminal mono-PEGylation on biological activity and pharmacokinetics.奥曲肽的聚乙二醇化：II. N端单聚乙二醇化对生物活性和药代动力学的影响。

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PEGylation of octreotide: I. Separation of positional isomers and stability against acylation by poly(D,L-lactide-co-glycolide).奥曲肽的聚乙二醇化：I. 位置异构体的分离及对聚（D，L-丙交酯-共-乙交酯）酰化的稳定性

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MALDI-TOF MS analysis of soluble PEG based multi-step synthetic reaction mixtures with automated detection of reaction failure.基于基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）对基于聚乙二醇（PEG）的多步合成反应混合物进行分析，并自动检测反应失败情况。

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