Grigsby Perry W., Dehdashti Farrokh, Siegel Barry A.
Mallinckrodt Institute of Radiology, Washington University Medical Center, St. Louis, MO, USA
Clin Positron Imaging. 1999 Mar;2(2):105-109. doi: 10.1016/s1095-0397(99)00008-4.
We performed fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) in 23 women with carcinoma of the uterine cervix to determine sites of metastatic disease. PET results were compared with those of computed tomography (CT) or lymphangiography. Increased FDG uptake was seen in the primary tumor in 10 of 11 patients with newly diagnosed disease. Additional sites of FDG uptake were identified in pelvic lymph nodes in 8, in extrapelvic lymph nodes in 5, and at distant metastatic sites in 3. In 12 patients with suspected recurrent disease, FDG uptake was present in 11; the presence of tumor was confirmed by CT in 10 and by biopsy in 9. For both patient groups, FDG-PET demonstrated more sites of tumor metastasis than did conventional imaging studies. Our results suggest that FDG-PET is a sensitive method for detecting regional and distant metastasis in patients with cervical carcinoma and has the potential to replace conventional imaging studies and allow more rational treatment planning.
我们对23例子宫颈癌女性患者进行了氟-18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET），以确定转移病灶的部位。将PET结果与计算机断层扫描（CT）或淋巴管造影结果进行比较。11例新诊断疾病患者中有10例在原发肿瘤中可见FDG摄取增加。在盆腔淋巴结中发现另外8例有FDG摄取，在盆腔外淋巴结中有5例，在远处转移部位有3例。在12例疑似复发疾病的患者中，11例存在FDG摄取；10例经CT证实有肿瘤，9例经活检证实。对于这两组患者，FDG-PET显示的肿瘤转移部位比传统影像学检查更多。我们的结果表明，FDG-PET是检测宫颈癌患者局部和远处转移的一种敏感方法，有可能取代传统影像学检查并实现更合理的治疗规划。
