Debord J, Voultoury J C, Lachatre G, Gay C, Favereau J P, Gay R
Service de Pharmacologie et Toxicologie, Chru Dupuytren, Limoges, France.
Eur J Clin Pharmacol. 1992;43(4):435-6. doi: 10.1007/BF02220623.
The pharmacokinetics of amikacin has been studied in 40 intensive care unit patients using the bayesian estimation method implemented in the USC PC PACK program of Jelliffe. The volume of the central compartment was significantly higher in these patients than in the reference population, while other pharmacokinetic parameters did not differ significantly from the reference values. The population values may be employed, in addition to those supplied with the software, to adapt dosage regimens of amikacin in ICU patients.
使用杰利夫的南加州大学PC PACK程序中实施的贝叶斯估计方法，对40名重症监护病房患者的阿米卡星药代动力学进行了研究。这些患者的中央室容积显著高于参考人群，而其他药代动力学参数与参考值无显著差异。除软件提供的值外，人群值可用于调整重症监护病房患者的阿米卡星给药方案。
