氟哌啶醇敏感的σ位点在镇咳作用中的参与。

Involvement of haloperidol-sensitive sigma-sites in antitussive effects.

作者信息

Kamei J, Iwamoto Y, Kawashima N, Hitosugi H, Misawa M, Kasuya Y

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

出版信息

Eur J Pharmacol. 1992 Nov 24;224(1):39-43. doi: 10.1016/0014-2999(92)94815-d.

DOI:10.1016/0014-2999(92)94815-d

PMID:1451741

Abstract

The effects of selective sigma-ligands on the capsaicin-induced cough reflex in rats were studied. Intraperitoneal injection of (+)-N-allylnormetazocine ((+)-SKF-10,047) and N,N'-di(ortho-tolyl)guanidine (DTG) in doses that ranged from 0.3 to 3.0 mg/kg decreased the number of coughs dose dependently. The antitussive effects of these sigma-ligands were significantly attenuated by pretreatment with haloperidol. Pretreatment with haloperidol also markedly reduced the antitussive effects of (+/-)-pentazocine and dextromethorphan. These results suggest that haloperidol-sensitive sigma-sites may be involved in the regulation of coughs.

摘要

研究了选择性σ配体对大鼠辣椒素诱导咳嗽反射的影响。腹腔注射剂量为0.3至3.0mg/kg的（+）-N-烯丙基去甲左啡诺（（+）-SKF-10,047）和N，N'-二（邻甲苯基）胍（DTG）可使咳嗽次数呈剂量依赖性减少。氟哌啶醇预处理可显著减弱这些σ配体的镇咳作用。氟哌啶醇预处理也显著降低了（±）-喷他佐辛和右美沙芬的镇咳作用。这些结果表明对氟哌啶醇敏感的σ位点可能参与咳嗽的调节。