Punthakee Zubin, Legault Laurent, Polychronakos Constantin
Endocrinology and Metabolism, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
J Pediatr. 2003 Sep;143(3):402-5. doi: 10.1067/S0022-3476(03)00294-4.
Prednisolone has unknown growth-suppressing effects relative to other steroids. We retrospectively studied 9 children (6 with congenital adrenal hyperplasia, CAH) receiving hydrocortisone replacement after switching to prednisolone (dose ratio, 1:5). Growth velocity and, in patients with CAH, 17-OHP decreased significantly. Dose reduction reversed these effects. Roughly, growth suppression relative potency for prednisolone:hydrocortisone was 15:1.
相对于其他类固醇，泼尼松龙的生长抑制作用尚不清楚。我们回顾性研究了9名在改用泼尼松龙（剂量比为1:5）后接受氢化可的松替代治疗的儿童（6名患有先天性肾上腺皮质增生症，CAH）。生长速度以及CAH患者的17-OHP均显著下降。剂量减少可逆转这些影响。大致上，泼尼松龙与氢化可的松的生长抑制相对效力为15:1。
