Severson Christopher A, Wang Wengang, Pieribone Vincent A, Dohle Carolin I, Richerson George B
Department of Neurology, 333 Cedar Street, Yale University, New Haven, Connecticut 06510, USA.
Nat Neurosci. 2003 Nov;6(11):1139-40. doi: 10.1038/nn1130. Epub 2003 Sep 28.
Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.
延髓中的5-羟色胺能神经元是中枢呼吸化学感受器。我们在此表明，大鼠中脑中的5-羟色胺能神经元对二氧化碳/酸碱度的微小变化也具有高度化学敏感性，并且与大的穿通动脉密切相关。我们提出，中脑缝际神经元是血液二氧化碳的传感器，通过在呼吸性酸中毒时诱导觉醒、焦虑和脑血管张力变化来维持酸碱度稳态。
