选择性5-羟色胺再摄取抑制剂与自杀行为：合理的说法？
Suicidality with selective serotonin reuptake inhibitors: Valid claim?
作者信息
Lapierre Yvon D
机构信息
Journal of Psychiatry & Neuroscience.
出版信息
J Psychiatry Neurosci. 2003 Sep;28(5):340-7.
Abstract
The red flags raised by the 1990 clinical reports of increased suicidality associated with treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine were followed by anecdotal reports of similar symptoms with other antidepressants of the same class. Recent discussions by Healy have argued in favour of a suicidogenic potential of the SSRIs. This paper reviews the relevant literature addressing the epidemiological data of Western populations and the data accumulated from clinical trial databases in several countries. The evidence currently available does not support the hypothesis that antidepressants or, more specifically, SSRIs cause increased suicidality in patients with depression, nor do they appear to do so in patients treated with these drugs for other reasons.
摘要
1990年的临床报告指出，选择性5-羟色胺再摄取抑制剂（SSRI）氟西汀治疗会增加自杀倾向，这引发了警示信号，随后有轶事报道称，同一类别的其他抗抑郁药也有类似症状。希利最近的讨论支持了SSRI具有潜在自杀诱导作用的观点。本文回顾了相关文献，涉及西方人群的流行病学数据以及几个国家临床试验数据库积累的数据。目前可得的证据并不支持抗抑郁药，更具体地说是SSRI会导致抑郁症患者自杀倾向增加这一假说，而且在因其他原因使用这些药物治疗的患者中似乎也并非如此。
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本文引用的文献
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Antidepressants and suicide: risk-benefit conundrums.抗抑郁药与自杀：风险-效益难题
J Psychiatry Neurosci. 2003 Sep;28(5):331-7.
2
Are placebo controls necessary to test new antidepressants and anxiolytics?测试新型抗抑郁药和抗焦虑药是否需要安慰剂对照？
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Adequacy of antidepressant treatment after discharge and the occurrence of suicidal acts in major depression: a prospective study.出院后抗抑郁治疗的充分性与重度抑郁症患者自杀行为的发生：一项前瞻性研究。
Am J Psychiatry. 2002 Oct;159(10):1746-51. doi: 10.1176/appi.ajp.159.10.1746.
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Mortality of patients with mood disorders: follow-up over 34-38 years.情绪障碍患者的死亡率：34至38年的随访
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Improvements in the recognition and treatment of depression and decreasing suicide rates.抑郁症识别与治疗方面的改善以及自杀率的下降。
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