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Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain.

作者信息

Luccarini Philippe, Henry Mélaine, Alvarez Pedro, Gaydier Anne-Marie, Dallel Radhouane

机构信息

INSERM E 0216, Neurobiologie de la Douleur Trigéminale, Faculté de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000, Clermont-Ferrand, France.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):320-3. doi: 10.1007/s00210-003-0799-z. Epub 2003 Sep 27.

DOI:10.1007/s00210-003-0799-z
PMID:14517596
Abstract

This study investigated the role of neurokinin 1 receptors (NK1R) in inflammatory cutaneous orofacial pain. The effects of subcutaneous and intracisternal administration of the NK1R antagonist SR140333 on the face rubbing response provoked by injection of 50 micro l of 1.5% formalin into the vibrissa pad were examined. Subcutaneous administration of SR140333 (5, 15, 30 mg/kg) induced a dose-related depressant effect on both the first and second phases of the formalin test. In contrast, intracisternal administration of SR140333 (10, 30, 60, 90 microg) produced a decrease only on the second phase with an apparent ceiling effect at approximately 50%. These data suggest that persistent nociceptive effects associated with orofacial cutaneous inflammation depend at least in part on the activation of NK1R.

摘要

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本文引用的文献

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Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.蛋白酶激活受体-2与痛觉过敏：一条新的疼痛通路。
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Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.给予神经激肽-1受体激动剂[ SAR9，MET（O2）11]P物质后豚鼠脑内Fos样免疫反应性的分布
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Evidence for tonic activation of NK-1 receptors during the second phase of the formalin test in the Rat.大鼠福尔马林试验第二阶段中NK-1受体紧张性激活的证据。
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Alterations in neurokinin A-, substance P- and calcitonin gene-related peptide immunoreactivities in the caudal trigeminal nucleus of the rat following electrical stimulation of the trigeminal ganglion.三叉神经节电刺激后大鼠尾侧三叉神经核中神经激肽A、P物质和降钙素基因相关肽免疫反应性的变化。
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