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A consensus repeat sequence from the human insulin gene linked polymorphic region adopts multiple quadriplex DNA structures in vitro.

作者信息

Hammond-Kosack M C, Docherty K

机构信息

Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.

出版信息

FEBS Lett. 1992 Apr 13;301(1):79-82. doi: 10.1016/0014-5793(92)80214-2.

DOI:10.1016/0014-5793(92)80214-2
PMID:1451791
Abstract

A hypervariable region consisting of repeats of a 14 base pair (bp) consensus sequence ACAGGGGT(G/C)(T/C)GGGG is located 363 bp upstream of the human insulin gene. Different repeat numbers of this oligonucleotide give rise to a polymorphism, and so this region is commonly known as the insulin gene linked polymorphic region (ILPR). Here we present evidence, based on the mobility in non-denaturing polyacrylamide gels of two dissimilarly sized oligonucleotides containing the ILPR consensus sequence, that this sequence can adopt a number of quadriplex DNA structures in vitro.

摘要

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