Peiper M, Goedegebuure P S, Eberlein T J, Broelsch C E
Chirurgische Klinik, Abteilung für Allgemeinchirurgie, Universitäts-Krankenhaus Eppendorf, Hamburg.
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):59-62.
Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.
细胞毒性T淋巴细胞由一种新建立的胰腺癌细胞系的肿瘤浸润淋巴细胞产生，其能显著裂解自体肿瘤细胞，且受HLA - I类分子限制。ICAM - 1阳性肿瘤克隆比ICAM - 1阴性克隆的裂解程度显著更高。用γ干扰素刺激导致ICAM - 1表达增加且裂解程度显著更高，这被抗ICAM - 1单克隆抗体所抑制。
