小鼠新生脾细胞与BW 5147胸腺瘤细胞融合产生的NSF17因子对细胞免疫的下调作用。
Down-regulating effect on cellular immunity of the NSF17 factor produced by murine neonatal spleen cells fused with BW 5147 thymoma cells.
作者信息
Bubak-Satora M, Machala O, Kubera M, Mazur-Kolecka B, Skowron-Cendrzak A
机构信息
Department of Immunobiology, Polish Academy of Sciences, Kraków.
出版信息
Folia Biol (Krakow). 1992;40(1-2):79-82.
PMID:1451838
Abstract
The non-specific factor NSF17 produced by mouse newborn splenocytes fused with BW 5147 thymoma cells was tested in vivo for its immunosuppressive activity. NSF17 administered i.p. in a single dose into adult mice significantly decreased the PHA-induced proliferative response of lymphocytes, regional graft-versus-host reaction, and delayed-type hypersensitivity.
摘要
对由小鼠新生脾细胞与BW 5147胸腺瘤细胞融合产生的非特异性因子NSF17进行了体内免疫抑制活性测试。将NSF17以单剂量腹腔注射给成年小鼠后，显著降低了淋巴细胞的PHA诱导增殖反应、局部移植物抗宿主反应和迟发型超敏反应。
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