Messinger-Rapport Barbara J
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation, OH 44195, USA.
Cleve Clin J Med. 2003 Sep;70(9):762, 764, 766-70 passim. doi: 10.3949/ccjm.70.9.762.
Alzheimer disease follows a pattern of gradual cognitive, behavioral, and functional decline. Other causes of dementia have overlapping presentations, but with important differences. Most patients with mild to moderate dementia should be treated with cholinesterase inhibitors to temporarily stabilize symptoms and delay clinically important end points. Memantine, an N-methyl-D-aspartate antagonist, may soon be available to treat moderate to severe dementia.
阿尔茨海默病呈现出认知、行为和功能逐渐衰退的模式。其他痴呆病因有重叠的表现,但也有重要差异。大多数轻至中度痴呆患者应使用胆碱酯酶抑制剂进行治疗,以暂时稳定症状并延缓具有临床意义的终点。美金刚,一种N-甲基-D-天冬氨酸拮抗剂,可能很快可用于治疗中至重度痴呆。