用于氧基和硫基亲核试剂可逆加成的新型迈克尔受体基团的鉴定。阿夫拉维胺3-亚烷基-3H-吲哚1-氧化物官能团的合成与反应活性。
Identification of a novel Michael acceptor group for the reversible addition of oxygen- and sulfur-based nucleophiles. Synthesis and reactivity of the 3-alkylidene-3H-indole 1-oxide function of avrainvillamide.
作者信息
Myers Andrew G, Herzon Seth B
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
J Am Chem Soc. 2003 Oct 8;125(40):12080-1. doi: 10.1021/ja0372006.
PMID:14518979
Abstract
The 3-alkylidene-3H-indole 1-oxide functional group found in the naturally occurring alkaloid avrainvillamide has been synthesized by a cross coupling-reductive condensation sequence and found to undergo reversible addition of oxygen- and sulfur-based nucleophiles.
摘要
天然存在的生物碱阿夫拉维胺中发现的3-亚烷基-3H-吲哚1-氧化物官能团已通过交叉偶联-还原缩合序列合成，并发现它能与基于氧和硫的亲核试剂发生可逆加成反应。
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