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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

作者信息

Carman Christopher V, Springer Timothy A

机构信息

Center for Blood Research, Harvard Medical School, Department of Pathology, 200 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Curr Opin Cell Biol. 2003 Oct;15(5):547-56. doi: 10.1016/j.ceb.2003.08.003.

DOI:10.1016/j.ceb.2003.08.003
PMID:14519389
Abstract

Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

摘要

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