Warter S, Bon C, Ebtinger R, Clavert J
Ann Med Psychol (Paris). 1977 Jan;1(1):51-61 contd.
This report brings to light the results of cytogenetic study carried out on 350 mentally retarded persons (medium: Group I, deep Group II). In 8,2% and 12,56% of the cases a chromosomic abnormality is observed (mainly trisomy 21). These percentages are in correlation with the results of other studies. Ante and peri natal pathology plays a very important part among exogenous factors. In numerous cases a multifactors etiology can be found as the cause of this mental retardation, the effect of an initial organic mental retardation being aggravated by precocious affective perturbations. For those cases without apparent etiology, a teratologic origin may be thought as their cause.
本报告揭示了对350名智力迟钝者(中度:第一组,重度:第二组)进行细胞遗传学研究的结果。在8.2%和12.56%的病例中观察到染色体异常(主要是21三体)。这些百分比与其他研究结果相关。产前和围产期病理在外源性因素中起非常重要的作用。在许多病例中,可以发现多因素病因是这种智力迟钝的原因,初始器质性智力迟钝的影响因早熟的情感紊乱而加重。对于那些没有明显病因的病例,可能认为其病因是致畸因素。