Konishi Yutaka, Kubo Kazuo, Shimizu Makoto
Applied Bioresearch Center, Research & Development Department, Kirin Brewery Co., Ltd., Gunma, Japan.
Biosci Biotechnol Biochem. 2003 Sep;67(9):2014-7. doi: 10.1271/bbb.67.2014.
The structural specificity of the monocarboxylic acid transporter (MCT) for the transport of phenolic acids was investigated by measuring the inhibitory effect on the fluorescein transport in Caco-2 cell monolayers. Although most of the monohydroxylated derivatives had an inhibitory effect, the di- and tri-hydroxylated ones did not. The methoxylated derivatives were more inhibitory than the hydroxylated ones in all the meta-substituted derivatives, suggesting that meta-hydroxylation of the substrate would decrease the affinity for MCT.
