Pukkala Eero, Kulmala Ilona, Hovi Sirpa-Liisa, Hemminki Elina, Keskimäki Ilmo, Pakkanen Matti, Lipworth Loren, Boice John D, McLaughlin Joseph K
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Ann Plast Surg. 2003 Oct;51(4):339-42; discussion 343-4. doi: 10.1097/01.sap.0000080407.97677.A5.
Mortality patterns among women with cosmetic breast implants have not been well characterized. We examined cause-specific mortality among women who underwent cosmetic breast implantation at major public hospitals and private clinics in Finland from 1970 through 2000. Causes of death through 2001 were identified through the national mortality register. Expected numbers of deaths were calculated on the basis of mortality rates in the general female population, and standardized mortality ratios (SMR), i.e. ratios of observed to expected deaths, and 95% confidence intervals (CI) were calculated. Among the 2166 women with cosmetic breast implants, we observed 31 deaths versus 32.1 expected. Overall disease mortality was below expectation, mainly due to low mortality from diseases of the circulatory system (SMR, 0.28; 95% CI, 0.03-1.02). Mortality from cancer was close to expectation. There was a statistically significant excess of suicide, based on 10 deaths, which was most pronounced during the first 5 years of follow-up (SMR, 4.26; 95% CI, 1.56-9.26). In conclusion, although based on small numbers, women with cosmetic breast implants did not experience higher mortality overall than women in the general population. The high suicide risk supports other studies and warrants further detailed investigation.
接受隆胸手术的女性的死亡模式尚未得到充分描述。我们调查了1970年至2000年期间在芬兰各大公立医院和私人诊所接受隆胸手术的女性的死因特异性死亡率。通过国家死亡率登记处确定了截至2001年的死亡原因。根据一般女性人群的死亡率计算预期死亡人数，并计算标准化死亡率（SMR），即观察到的死亡人数与预期死亡人数的比率，以及95%置信区间（CI）。在2166名接受隆胸手术的女性中，我们观察到31例死亡，而预期死亡人数为32.1例。总体疾病死亡率低于预期，主要是由于循环系统疾病的死亡率较低（SMR，0.28；95%CI，0.03-1.02）。癌症死亡率接近预期。基于10例死亡，自杀率在统计学上显著过高，在随访的前5年最为明显（SMR，4.26；95%CI，1.56-9.26）。总之，尽管样本数量较少，但接受隆胸手术的女性总体死亡率并不高于普通人群中的女性。高自杀风险支持了其他研究，值得进一步详细调查。
