Eva Lois J, MacLean Allan B, Reid Wendy M N, Rolfe Kerstin J, Perrett Christopher W
Department of Obstetrics and Gynecology, Royal Free and University College Medical School (Royal Free Campus), London, United Kingdom.
Am J Obstet Gynecol. 2003 Aug;189(2):458-61. doi: 10.1067/s0002-9378(03)00365-x.
A pilot study was performed to investigate the relationship between vulvar vestibulitis syndrome and estrogen receptor expression.
Women with a diagnosis of vulvar vestibulitis syndrome had tissue samples taken for vulvar estrogen receptor-alpha expression and this was compared with a control group.
The study group showed a significant decrease in estrogen receptor expression, and 50% of the samples did not exhibit any receptor expression.
There appears to be a subgroup of women with vulvar vestibulitis syndrome who exhibit abnormal estrogen receptor-alpha expression. This may be helpful in explaining why some women are resistant to medical treatment and may allow treatment to be prescribed more effectively.
进行一项初步研究以调查外阴前庭炎综合征与雌激素受体表达之间的关系。
对诊断为外阴前庭炎综合征的女性采集组织样本以检测外阴雌激素受体α的表达，并与对照组进行比较。
研究组雌激素受体表达显著降低，50%的样本未表现出任何受体表达。
似乎有一部分外阴前庭炎综合征女性存在异常的雌激素受体α表达。这可能有助于解释为何一些女性对药物治疗有抵抗性，并可能使治疗方案的开具更有效。
