Siega-Riz Anna Maria, Promislow Joanne H E, Savitz David A, Thorp John M, McDonald Thad
Department of Nutrition, School of Public Health, the Carolina Population Center, University of North Carolina, Chapel Hill, USA.
Am J Obstet Gynecol. 2003 Aug;189(2):519-25. doi: 10.1067/s0002-9378(03)00363-6.
Ascorbic acid deficiency may lead to premature rupture of the membranes.
The study included a prospective cohort of pregnant women, aged >/=16 years, with singleton gestations who received care at one of four prenatal clinics in central North Carolina from 1995 through 1998. Vitamin C intake preconceptionally and during the second trimester was examined for its association with preterm delivery and subsets of preterm labor, premature rupture of the membranes, and medical induction in 2064 women.
Women who had total vitamin C intakes of <10th percentile preconceptionally had twice the risk of preterm delivery because of premature rupture of the membranes (relative risk, 2.2; 95% CI, 1.1, 4.5). This risk was attenuated slightly for second-trimester intake (relative risk, 1.7; 95% CI, 0.8, 3.5). The elevated risk of preterm premature rupture of the membranes was greatest for women with a low vitamin C intake during both time periods.
Because diet and supplement use are modifiable behaviors, corroboration of these findings would suggest a possible intervention strategy.
维生素C缺乏可能导致胎膜早破。
该研究纳入了1995年至1998年在北卡罗来纳州中部四家产前诊所之一接受护理的年龄≥16岁的单胎妊娠孕妇前瞻性队列。对2064名女性孕前及孕中期的维生素C摄入量与早产及早产亚组、胎膜早破和引产的相关性进行了研究。
孕前维生素C总摄入量处于第10百分位数以下的女性，因胎膜早破导致早产的风险是其他人的两倍（相对风险为2.2；95%可信区间为1.1至4.5）。孕中期摄入量的这种风险略有降低（相对风险为1.7；95%可信区间为0.8至3.5）。在两个时间段维生素C摄入量都低的女性，胎膜早破早产的风险升高最为明显。
由于饮食和补充剂的使用是可改变的行为，这些发现若得到证实，将提示一种可能的干预策略。
