Di Lieto Andrea, Pollio Fabrizio, De Falco Marianna, Iannotti Francesca, Mascolo Massimo, Somma Pasquale, Staibano Stefania
Department of Obstetrical-Gynaecological, University Federico II of Naples, Naples, Italy.
Am J Obstet Gynecol. 2003 Aug;189(2):594-600. doi: 10.1067/s0002-9378(03)00468-x.
The purpose of this study was to evaluate collagen content and platelet-derived growth factor, vascular endothelial growth factor, and connective tissue growth factor expression in the myometrium of the uterine lower segment from a patient with type IA osteogenesis imperfecta with recurrent uterine rupture and to evaluate the existence of a relationship between the rare recurrent uterine rupture and the tissue disorders of type IA osteogenesis imperfecta.
Collagen content and platelet-derived growth factor, vascular endothelial growth factor, and connective tissue growth factor expression in the uterine lower segment were assessed in the patient with type IA osteogenesis imperfecta and in eight otherwise healthy ("control") patients.
Type IA osteogenesis imperfecta contained less total collagen amount, with no difference in type III collagen expression and showed increased levels of platelet-derived growth factor and vascular endothelial growth factor in myometrial smooth muscle cells. No difference was observed in connective tissue growth factor expression.
These findings confirm the diminished collagen amount in myometrium from osteogenesis imperfecta and show the presence of additional pathogenetic mechanisms. A relationship is hypothesized between the underlying myometrial biochemical modifications and the recurrent uterine rupture.
本研究旨在评估1A型成骨不全症伴复发性子宫破裂患者子宫下段肌层中的胶原蛋白含量以及血小板衍生生长因子、血管内皮生长因子和结缔组织生长因子的表达情况，并评估罕见的复发性子宫破裂与1A型成骨不全症组织病变之间是否存在关联。
对1A型成骨不全症患者及8名健康（“对照”）患者的子宫下段胶原蛋白含量以及血小板衍生生长因子、血管内皮生长因子和结缔组织生长因子的表达情况进行评估。
1A型成骨不全症患者的总胶原蛋白含量较少，III型胶原蛋白表达无差异，且肌层平滑肌细胞中的血小板衍生生长因子和血管内皮生长因子水平升高。结缔组织生长因子表达未观察到差异。
这些发现证实了成骨不全症患者肌层中胶原蛋白含量减少，并显示存在其他致病机制。推测潜在的肌层生化改变与复发性子宫破裂之间存在关联。
