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靶向CD40的腺病毒GM-CSF基因转移在细胞因子剥夺时增强并延长人慢性粒细胞白血病来源的树突状细胞的成熟。

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation.

作者信息

Stam A G M, Santegoets S J A M, Westers T M, Sombroek C C, Janssen J J W M, Tillman B W, van de Loosdrecht A A, Pinedo H M, Curiel D T, Ossenkoppele G J, Scheper R J, de Gruijl T D

机构信息

Department of Pathology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

出版信息

Br J Cancer. 2003 Oct 6;89(7):1162-5. doi: 10.1038/sj.bjc.6601225.

DOI:10.1038/sj.bjc.6601225
PMID:14520439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2394320/
Abstract

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

摘要

用自体白血病来源的树突状细胞（DC）进行疫苗接种是慢性粒细胞白血病（CML）的一种辅助治疗选择。在此，我们表明，将GM-CSF进行高效的靶向CD40的腺病毒基因转移至CML来源的DC，可在无外源性细胞因子的情况下诱导长期成熟，因此可能确保接种疫苗后对CML特异性T细胞的持久刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/2394320/fb1a5ce2c525/89-6601225f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/2394320/0b31c42307a6/89-6601225f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/2394320/fb1a5ce2c525/89-6601225f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/2394320/0b31c42307a6/89-6601225f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/2394320/fb1a5ce2c525/89-6601225f2.jpg

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本文引用的文献

1
Vaccination of chronic myeloid leukemia patients with autologous in vitro cultured leukemic dendritic cells.用自体体外培养的白血病树突状细胞对慢性髓性白血病患者进行疫苗接种。
Leukemia. 2003 Jul;17(7):1424-6. doi: 10.1038/sj.leu.2402979.
2
CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.CD40刺激通过诱导强大的全身性细胞毒性T淋巴细胞免疫，导致对CD40（-）肿瘤的有效治疗。
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5561-6. doi: 10.1073/pnas.082107699. Epub 2002 Apr 2.
3
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.
基于树突状细胞的癌症疫苗在血液系统恶性肿瘤中的临床试验。
Hum Vaccin Immunother. 2014;10(11):3125-31. doi: 10.4161/21645515.2014.982993.
在体内稳态条件下，树突状细胞可诱导外周T细胞无反应性。
J Exp Med. 2001 Sep 17;194(6):769-79. doi: 10.1084/jem.194.6.769.
4
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.通过用同种异体未成熟人树突状细胞反复刺激诱导产生具有调节特性的分泌白细胞介素10、不增殖的CD4(+) T细胞。
J Exp Med. 2000 Nov 6;192(9):1213-22. doi: 10.1084/jem.192.9.1213.
5
Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway.重组腺病毒通过NF-κB依赖途径诱导树突状细胞成熟。
J Virol. 2000 Oct;74(20):9617-28. doi: 10.1128/jvi.74.20.9617-9628.2000.
6
Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector.树突状细胞的成熟伴随着CD40靶向腺病毒载体的高效基因转移。
J Immunol. 1999 Jun 1;162(11):6378-83.
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Nature. 1998 Jun 4;393(6684):480-3. doi: 10.1038/31002.
8
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Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response.由慢性粒细胞白血病患者血液前体细胞生成的树突状细胞携带费城染色体易位，且能诱导特异性针对慢性粒细胞白血病的原发性细胞毒性T细胞反应。
Genes Chromosomes Cancer. 1997 Nov;20(3):215-23. doi: 10.1002/(sici)1098-2264(199711)20:3<215::aid-gcc1>3.0.co;2-5.
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