Ammenti A, Nitsch M
Department of Pediatrics, University of Parma School of Medicine, Parma, Italy.
Klin Padiatr. 2003 Sep-Oct;215(5):283-5. doi: 10.1055/s-2003-42665.
In Osteogenesis Imperfecta severity of disease and reduced physical activity have been considered the main factors contributing to hypercalciuria; however, its pathogenesis in Osteogenesis Imperfecta Type I, in which mobility is normal, is still unclear.
PATIENT, METHODS AND RESULTS: We describe a patient with Osteogenesis Imperfecta Type I and hypercalciuria, in whom measurement of calcium intake, plasma 1 - 25(OH) (2) Vitamin D, fasting calciuria and tubular proteinuria led us to exclude an absorptive or renal component in the pathogenesis of hypercalciuria.
We believe that hypercalciuria is determined by bone disease in Osteogenesis Imperfecta Type I. This condition should be added to the causes of normocalcemic hypercalciuria in children and the mildest forms should be differentiated from Idiopathic Hypercalciuria.
在成骨不全症中，疾病严重程度和体力活动减少被认为是导致高钙尿症的主要因素；然而，在I型成骨不全症中，其发病机制尚不清楚，该型患者活动能力正常。
患者、方法与结果：我们描述了一名患有I型成骨不全症和高钙尿症的患者，通过测量钙摄入量、血浆1,25(OH)₂维生素D、空腹尿钙和肾小管蛋白尿，我们排除了高钙尿症发病机制中的吸收性或肾脏因素。
我们认为，I型成骨不全症中的高钙尿症是由骨病决定的。这种情况应被列入儿童正常血钙性高钙尿症的病因中，最轻微的形式应与特发性高钙尿症相鉴别。
