Utzig N, Friedrich B, Burtzlaff C, Lauffer H
Ernst-Moritz-Arndt Universität Greifswald, Klinik für Kinder- und Jugendmedizin, Abteilung für Neuropädiatrie und Stoffwechselkrankheiten.
Klin Padiatr. 2003 Sep-Oct;215(5):286-7. doi: 10.1055/s-2003-42666.
Enteroviruses are common with infections of the CNS, such as encephalitis and myelitis, but they may cause various diseases in different organ systems, particulary with fatal outcome. Pleconaril is a new orally acting antiviral drug with broad anti-picornavirus activity, which provides to treat rhinoviral and enteroviral infections. To explain the importance for clinical use, we report a case of severe enteroviral infections of the CNS, treated by Pleconaril. A 14 year old girl presented with a severe polio- like myelitis including flaccid paraparesis and urinary incontinence due to Coxsackievirus-infection. Because of prolonged course and virus persistence we treated with Pleconaril, after treatment a remarkable improvement could be noticed, continency and the ability to walk without aid were regained within a few weeks. With the development of new antiviral substances we are now given more opportunities to treat infectious conditions of the central nervous system. We suggest to include enteroviruses in diagnostic procedures since there is an effective treatment with the new drug Pleconaril available.
肠道病毒常引起中枢神经系统感染，如脑炎和脊髓炎，但它们可能在不同器官系统中引发各种疾病，尤其是导致致命后果。普来可那立是一种新型口服抗病毒药物，具有广泛的抗微小核糖核酸病毒活性，可用于治疗鼻病毒和肠道病毒感染。为说明其临床应用的重要性，我们报告一例用普来可那立治疗的严重肠道病毒中枢神经系统感染病例。一名14岁女孩因柯萨奇病毒感染出现严重的脊髓灰质炎样脊髓炎，包括弛缓性截瘫和尿失禁。由于病程延长且病毒持续存在，我们用普来可那立进行治疗，治疗后有显著改善，几周内恢复了自主排尿和独立行走能力。随着新型抗病毒药物的研发，我们现在有更多机会治疗中枢神经系统感染性疾病。鉴于有有效的新药普来可那立可供使用，我们建议在诊断程序中纳入肠道病毒检测。
