Taub Rebecca
Bristol-Myers Squibb Co., PO Box 5100, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
J Clin Invest. 2003 Oct;112(7):978-80. doi: 10.1172/JCI19974.
Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.