Bhatia S, Verma I C, Shrivastava S
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Indian Pediatr. 1992 Sep;29(9):1113-6.
We evaluated the utility of echocardiography in assessing the frequency and nature of cardiac malformations in children with Down syndrome. Fifty cases of chromosomally proven Down syndrome were studied. A physical examination, electro cardiogram, radiograph of chest and two-dimensional echocardiography was performed on all patients. Twenty-two (44%) children had heart diseases. Endocardial-cushion-defect was the commonest anomaly, followed by ventricular septal defect. Three children with heart disease were asymptomatic and had normal X-ray films of chest and ECGs. The prevalence and specific type of congenital heart disease in this study is comparable to the studies using invasive means for diagnosis. The study further suggests that clinical examination of the cardiovascular system alone may not be sufficient in detecting heart disease. Two-dimensional echocardiography offers an excellent non-invasive tool for diagnosing cardiac malformations in Down syndrome.
我们评估了超声心动图在评估唐氏综合征患儿心脏畸形的频率和性质方面的效用。研究了50例经染色体证实的唐氏综合征病例。对所有患者进行了体格检查、心电图、胸部X光片和二维超声心动图检查。22名（44%）儿童患有心脏病。心内膜垫缺损是最常见的异常，其次是室间隔缺损。3名患有心脏病的儿童无症状，胸部X光片和心电图正常。本研究中先天性心脏病的患病率和具体类型与使用侵入性诊断方法的研究相当。该研究进一步表明，仅对心血管系统进行临床检查可能不足以检测出心脏病。二维超声心动图为诊断唐氏综合征患者的心脏畸形提供了一种出色的非侵入性工具。
