Raulet David H
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720-3200, USA.
Nat Rev Immunol. 2003 Oct;3(10):781-90. doi: 10.1038/nri1199.
According to present concepts, innate immunity is regulated by receptors that determine danger levels by responding to molecules that are associated with infection or cellular distress. NKG2D is, perhaps, the best characterized receptor that is associated with responses to cellular distress, defined as transformation, infection or cell stress. This review summarizes recent findings that concern NKG2D, its ligands, its signalling properties and its role in disease, and provides a framework for considering how the induction of immune responses can be regulated by cellular responses to injury.
根据目前的概念，固有免疫由一些受体调控，这些受体通过对与感染或细胞应激相关的分子作出反应来确定危险程度。NKG2D可能是与细胞应激反应相关的特征最明确的受体，细胞应激被定义为转化、感染或细胞应激。这篇综述总结了有关NKG2D、其配体、其信号传导特性及其在疾病中的作用的最新发现，并提供了一个框架，以思考免疫反应的诱导如何通过细胞对损伤的反应来调控。
