Bednarz Bronisław, Chamiec Tomasz, Ceremuzyński Leszek
Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
Kardiol Pol. 2003 May;58(5):375-9.
Antioxidant vitamins C and E inhibit neutrophil-mediated production of free radicals in acute myocardial infarction (MI) which may limit MI size and improve myocardial perfusion.
To examine whether treatment with vitamin C and E reduces inhomogeneity of repolarisation in patients with acute MI.
In this double-blind, placebo-controlled randomised trial 37 patients with acute MI were enrolled and assigned to vitamin C and E (600 mg/day each) or placebo treatment, starting on the first day of acute MI and lasting for 14 days. Inhomogeneity of repolarisation was assessed by examining QT interval dispersion (QTd), measured both at rest and at the end of sub-maximal exercise test, performed before discharge.
Baseline QTd was similar in both groups, however, exercise-induced QTd was significantly lower in patients treated with antioxidant vitamins compared with the placebo group (59 +/- 20 msec vs 74 +/- 24 msec, p<0.05).
抗氧化维生素C和E可抑制急性心肌梗死（MI）中中性粒细胞介导的自由基生成，这可能会限制MI面积并改善心肌灌注。
研究维生素C和E治疗是否能降低急性MI患者复极的不均一性。
在这项双盲、安慰剂对照的随机试验中，纳入37例急性MI患者，从急性MI的第一天开始，给予维生素C和E（各600毫克/天）或安慰剂治疗，持续14天。通过检查QT间期离散度（QTd）评估复极的不均一性，QTd在静息时以及出院前进行的次极量运动试验结束时测量。
两组的基线QTd相似，然而，与安慰剂组相比，接受抗氧化维生素治疗的患者运动诱导的QTd显著更低（59±20毫秒对74±24毫秒，p<0.05）。
