Ackerstaff Ellen, Glunde Kristine, Bhujwalla Zaver M
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
J Cell Biochem. 2003 Oct 15;90(3):525-33. doi: 10.1002/jcb.10659.
The experience of treating cancer over the past several decades overwhelmingly demonstrates that the disease continues to evade the vast array of drugs and treatment modalities available in the twenty-first century. This is not surprising in view of the complexity of this disease, and the multiplicities of pathways available to the cancer cell to enable its survival. Although the progression of cancer arrives at a common end point of cachexia, organ failure, and death, common pathways are rare in cancer. Identifying and targeting common pathways that would act across these levels of multiplicity is essential for the successful treatment of this disease. Over the past decade, one common characteristic consistently revealed by magnetic resonance spectroscopic studies is the elevation of phosphocholine and total choline-containing compounds in cancer cells and solid tumors. This elevation has been observed in almost every single cancer type studied with NMR spectroscopy and can be used as an endogenous biomarker of cancer. In this article, we have summarized some of the observations on the choline phospholipid metabolism of cancer cells and tumors, and make a case for targeting the aberrant choline phospholipid metabolism of cancer cells.
在过去几十年里治疗癌症的经验充分表明，在21世纪，这种疾病仍然能够避开大量可用的药物和治疗方式。鉴于这种疾病的复杂性以及癌细胞能够通过多种途径存活，这并不令人惊讶。尽管癌症的发展最终都会导致恶病质、器官衰竭和死亡，但癌症中很少有共同的途径。识别并针对这些多样化层面发挥作用的共同途径对于成功治疗这种疾病至关重要。在过去十年中，磁共振波谱研究始终揭示出的一个共同特征是癌细胞和实体瘤中磷酸胆碱和总含胆碱化合物含量升高。在用核磁共振波谱研究的几乎每一种癌症类型中都观察到了这种升高现象，并且它可以用作癌症的内源性生物标志物。在本文中，我们总结了一些关于癌细胞和肿瘤胆碱磷脂代谢的观察结果，并提出了针对癌细胞异常胆碱磷脂代谢的理由。
