Gul Y A, Prasannan S, Hairuszah I
Department of Surgery, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia.
Acta Chir Belg. 2003 Aug;103(4):420-2. doi: 10.1080/00015458.2003.11679458.
Primary malignant melanoma arising in the oesophagus is a rare condition with a dismal prognosis. The diagnosis is often made following surgical resection even though the endoscopic features may be pathognomonic. The classical treatment is oesophagectomy even though the advanced disease stage at the time of presentation and aggressive biological behaviour of the tumour usually results in a fatal outcome. We report the case of a male patient initially diagnosed with squamous oesophageal carcinoma and treated with conventional neo-adjuvant chemo-radiotherapy. Poor clinical and radiological response resulted in a review of the original histology confirming a diagnosis of primary malignant melanoma of the oesophagus. The subsequent alteration in management conferred the patient an improved quality of life. A short review of the literature on primary malignant melanoma of the oesophagus supplements this case report.
原发性食管恶性黑色素瘤是一种罕见疾病，预后不佳。即便内镜特征可能具有诊断特异性，但诊断通常在手术切除后才能做出。经典治疗方法是食管切除术，不过由于就诊时疾病已处于晚期且肿瘤具有侵袭性生物学行为，通常会导致致命后果。我们报告一例男性患者，最初诊断为食管鳞状细胞癌，并接受了传统新辅助放化疗。临床和影像学反应不佳促使对原始组织学进行复查，确诊为原发性食管恶性黑色素瘤。随后治疗方案的改变使患者生活质量得到改善。对食管原发性恶性黑色素瘤的文献进行简短综述以补充本病例报告。
