Chciałowski Andrzej
Wojskowy Instytut Medyczny, Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii CSK MON w Warszawie.
Pol Merkur Lekarski. 2003 Jun;14(84):500-4.
Inflammation is a defensive reaction of an organism in response to injuring factors and is characterised by effector cells infiltration. Adhesion molecules are involved in their ordered influx. These molecules are glycoprotein particles present on cell surface and on intracellular matrix proteins. Cytokines, chemokines and other inflammatory process mediators modulate the expression of adhesion molecules. Anti-adhesion therapy involves many techniques. Most frequently monoclonal antibodies are used. Other forms of therapy contribute to blocking the synthesis of molecules at transcription level or to inhibition of their transfer from cell interior to its surface. Soluble molecule forms or their receptors are also applied.
炎症是机体对损伤因子的防御反应，其特征是效应细胞浸润。黏附分子参与它们的有序流入。这些分子是存在于细胞表面和细胞内基质蛋白上的糖蛋白颗粒。细胞因子、趋化因子和其他炎症过程介质调节黏附分子的表达。抗黏附治疗涉及多种技术。最常用的是单克隆抗体。其他治疗形式有助于在转录水平阻断分子的合成或抑制其从细胞内部转移到细胞表面。也应用可溶性分子形式或其受体。
