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[过敏性眼病的临床表现、诊断与治疗]

[Clinical picture, diagnosis and therapy of allergic eye diseases].

作者信息

Groblewska Anna

机构信息

Klinika Okulistyki Instytutu Centrum Zdrowia Matki Polki w Łodzi.

出版信息

Pol Merkur Lekarski. 2003 Jun;14(84):719-22.

Abstract

Ocular allergic disorders can be a component of systemic or local allergies. The importance of ocular allergy results from its incidence rather than from its severity, however, some of them are vision-threatening. The majority of ocular allergies affect the conjunctiva, eyelids and sometimes cornea that is exposed to the environment and is the place of interaction between allergens and immunocompetent cells. Different types of allergic disorders in the eye may have similar signs and symptoms, but each has its own pathognomonic characteristics, which help to diagnose, differentiate and choose the most suitable therapy. Ocular allergic diseases are classified into six categories: SAC, PAC, VKC, AKC, GPC and ConBC. In 2001 EAACI suggested new classification, also of allergic conjunctivitis, into IgE-mediated and non-IgE-mediated conjunctivitis. IgE-mediated conjunctivitis may be divided into intermittent and persistent conjunctivitis. Persistent allergic conjunctivitis is classified into vernal and atopic keratoconjunctivitis. Conjunctivitis contact allergy is a non-IgE form of allergic conjunctivitis. Currently available medications provide safe and effective management of most cases of ocular allergy. Drugs used in the treatment of ocular allergic disorders include mast cell stabilizers, antihistamines, steroids, NSAID's, artificial tears and others.

摘要

眼部过敏性疾病可能是全身或局部过敏的一部分。眼部过敏的重要性源于其发病率而非严重程度,然而,其中一些会威胁视力。大多数眼部过敏影响结膜、眼睑,有时还会影响暴露于环境中的角膜,角膜是变应原与免疫活性细胞相互作用的部位。眼睛中不同类型的过敏性疾病可能有相似的体征和症状,但每种都有其独特的特征,这有助于诊断、鉴别并选择最合适的治疗方法。眼部过敏性疾病分为六类:季节性变应性结膜炎(SAC)、常年性变应性结膜炎(PAC)、春季角结膜炎(VKC)、特应性角结膜炎(AKC)、巨乳头性结膜炎(GPC)和结膜嗜碱性粒细胞增多症(ConBC)。2001年,欧洲变态反应和临床免疫学会(EAACI)建议对过敏性结膜炎进行新的分类,分为IgE介导的和非IgE介导的结膜炎。IgE介导的结膜炎可分为间歇性和持续性结膜炎。持续性过敏性结膜炎分为春季角结膜炎和特应性角结膜炎。接触性过敏性结膜炎是过敏性结膜炎的非IgE形式。目前可用的药物能安全有效地治疗大多数眼部过敏病例。用于治疗眼部过敏性疾病的药物包括肥大细胞稳定剂、抗组胺药、类固醇、非甾体抗炎药、人工泪液等。

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