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移植前后运动对卫星细胞激活及骨骼肌移植再生的影响:小鼠的形态学和放射自显影研究

The effects of pre- and posttransplantation exercise on satellite cell activation and the regeneration of skeletal muscle transplants: a morphometric and autoradiographic study in mice.

作者信息

Roberts P, McGeachie J K

机构信息

Department of Anatomy and Human Biology, University of Western Australia, Nedlands.

出版信息

J Anat. 1992 Feb;180 ( Pt 1)(Pt 1):67-74.

PMID:1452483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1259608/
Abstract

The effects of pre- and posttransplantation exercise on satellite cell activation, and the eventual regeneration of skeletal muscle transplants, were studied histologically, morphometrically and autoradiographically. It was found that satellite cells in these transplants were synthesising DNA 30 h after transplantation, and the transplants appeared to be revascularising at 60 h after surgery. Respectively, this was 18 and 12 h earlier than found in previous studies on nonexercising muscle using the same techniques. The morphometric analysis showed hypertrophy of the muscle fibres of the exercised transplants when compared with controls, and also an increase in the capillarity of the exercised transplants.

摘要

对移植前后运动对卫星细胞激活以及骨骼肌移植最终再生的影响进行了组织学、形态计量学和放射自显影研究。结果发现,这些移植组织中的卫星细胞在移植后30小时合成DNA,并且移植组织在手术后60小时似乎开始重新血管化。与之前使用相同技术对非运动肌肉进行的研究相比,这分别提前了18小时和12小时。形态计量分析表明,与对照组相比,运动后的移植肌肉纤维肥大,并且运动后的移植组织的毛细血管数量也增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a0/1259608/d2f2c60587dd/janat00150-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a0/1259608/2d8a58275737/janat00150-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a0/1259608/d2f2c60587dd/janat00150-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a0/1259608/2d8a58275737/janat00150-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a0/1259608/d2f2c60587dd/janat00150-0069-a.jpg

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本文引用的文献

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Exercise-induced adaptations of rat soleus muscle grafts.运动诱导的大鼠比目鱼肌移植适应
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Propranolol retards revascularisation and impedes early myogenesis in regenerating skeletal muscle transplants: an autoradiographic and morphometric study in mice.普萘洛尔延缓再生骨骼肌移植中的血管再生并阻碍早期肌生成:一项小鼠放射自显影和形态计量学研究。
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