Fareed J, Hoppenstedt D, Bick R L, Bacher P
Department of Pharmacology, Loyola University School of Medicine, Chicago, Illinois.
Hematol Oncol Clin North Am. 1992 Dec;6(6):1229-45.
The hemostatic and fibrinolytic systems contribute significantly to the overall pathophysiologic status of a patient in a given clinical setting. Drug modulation of these systems plays a crucial role in the facilitation of the therapeutic effects but may also produce bleeding or thrombotic disorders. Many drugs appear inert; they can, however, modulate both the hemostatic and fibrinolytic systems. Such effects depend on several factors, however, but are significant enough to be recognized for the optimal care of patients. Therefore, it is recommended that the hemostatic and fibrinolytic systems should be routinely monitored during drug delivery.
在特定临床环境中，止血和纤溶系统对患者的整体病理生理状态有显著影响。对这些系统的药物调节在促进治疗效果方面起着关键作用，但也可能导致出血或血栓形成性疾病。许多药物看似无活性；然而，它们能够调节止血和纤溶系统。不过，此类效应取决于多种因素，但其重要性足以在患者的最佳护理中得到认识。因此，建议在给药过程中常规监测止血和纤溶系统。
