Walker Candace, Thomas Janice, Allen Timothy S
Kentucky Correctional Psychiatric Center, 1612 Dawkins Road, LaGrange, Kentucky 40031, USA.
Int J Offender Ther Comp Criminol. 2003 Oct;47(5):556-67. doi: 10.1177/0306624X03253027.
There are few effective treatments of antisocial personality disorder (APD). Preliminary work suggests that the atypical antipsychotic quetiapine can decrease irritability, impulsivity, and aggressiveness. Data were collected from 4 patients with APD who were referred to a maximum-security inpatient psychiatric facility for pretrial evaluation and were treated with quetiapine. Quetiapine was effective in these patients as was indicated by a decrease in symptoms such as impulsivity, hostility, aggressiveness, irritability, and rage reactions. Typical dosage was 600 to 800 mg per day. Patients attributed their willingness to comply with quetiapine treatment to both the effectiveness of the drug and its favorable adverse-event profile. Quetiapine was successfully combined with mood stabilizers, particularly gabapentin, in patients with prominent affective instability. Quetiapine has demonstrated efficacy in aggression, impulsivity, and irritability and has proved to be an effective medication in these patients with APD. In addition, its favorable adverse-event profile makes patients willing to comply.
反社会人格障碍（APD）几乎没有有效的治疗方法。初步研究表明，非典型抗精神病药物喹硫平可以降低易怒性、冲动性和攻击性。研究人员收集了4例因审前评估被转至最高安全级别的住院精神科机构并接受喹硫平治疗的APD患者的数据。喹硫平对这些患者有效，这体现在冲动性、敌意、攻击性、易怒性和愤怒反应等症状有所减轻。典型剂量为每日600至800毫克。患者将他们愿意接受喹硫平治疗归因于药物的有效性及其良好的不良事件特征。在情感稳定性突出的患者中，喹硫平成功地与情绪稳定剂，尤其是加巴喷丁联合使用。喹硫平在攻击行为、冲动性和易怒性方面已显示出疗效，并已被证明是治疗这些APD患者的有效药物。此外，其良好的不良事件特征使患者愿意接受治疗。
