Berard P, Montegue A, Briot F, Harduin J C
CEA, DEN, DSP, LABM Saclay, 91191 Gif-sur Yvette Cedex, France.
Radiat Prot Dosimetry. 2003;105(1-4):447-50. doi: 10.1093/oxfordjournals.rpd.a006279.
Inter-laboratory tests are a means of assessing the analytical coherence of medical laboratories. In radiotoxicology, this kind of exercise makes it possible to keep up with laboratory know-how and with the evolution and relative performances of analytical techniques. The intercomparison exercises organised by PROCORAD (Association for the Promotion of Quality Controls in Radiotoxicological Bioassays) provide an opportunity to compare and contrast radiochemistry and metrology for the in vitro analysis of urine and faeces. For uranium compounds, the development of new techniques such as inductively coupled plasma-mass spectrometry (ICP-MS), alpha spectrometry, and laser spectrofluorimetry makes it possible to compare the effectiveness of these protocols with respect to radiation protection monitoring, both in routine and special situations. Detection limits, flexibility, repeatability, reproducibility and isotopic quantification are the criteria considered in this study. The authors present the evolution of performances for the analysis of uranium in urine over the years. However, the goal of the laboratories taking part in these annual exercises is not only to check the accuracy of their results but also to have analytical discussions and the opportunity to exchange experiences that will enrich the group's general competence.
实验室间测试是评估医学实验室分析一致性的一种手段。在放射毒理学中，这种活动有助于跟上实验室的专业知识以及分析技术的发展和相对性能。由PROCORAD（放射毒理学生物测定质量控制促进协会）组织的比对活动提供了一个机会，可对尿液和粪便体外分析的放射化学和计量学进行比较和对照。对于铀化合物，电感耦合等离子体质谱法（ICP-MS）、α能谱法和激光荧光光谱法等新技术的发展，使得在常规和特殊情况下，能够就辐射防护监测方面比较这些方法的有效性。本研究考虑的标准包括检测限、灵活性、重复性、再现性和同位素定量。作者展示了多年来尿液中铀分析性能的演变。然而，参与这些年度活动的实验室的目标不仅是检查其结果的准确性，还包括进行分析讨论以及有机会交流经验，从而丰富团队的总体能力。
