Emody L, Kerényi M, Nagy G
Department of Medical Microbiology and Immunology, University Medical School of Pécs, Szigeti ut 12, H-7624, Pécs, Hungary.
Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:29-33. doi: 10.1016/s0924-8579(03)00236-x.
Virulence factors of Escherichia coli are of two main types; those produced on the surface of the cell and those produced within the cell and then exported to the site of action. Those on the surface include different sorts of fimbriae that have a role in adhesion to the surface of host cells but may also have additional roles such as tissue invasion, biofilm formation or cytokine induction. The activities of cell wall components are discussed and several exported virulence factors are described that have anti host cell activities. Others virulence factors enable the bacteria to grow in an environment of iron restriction.
大肠杆菌的毒力因子主要有两种类型；一种是在细胞表面产生的，另一种是在细胞内产生然后输出到作用部位的。表面的毒力因子包括不同种类的菌毛，它们在粘附于宿主细胞表面方面发挥作用，但也可能有其他作用，如组织侵袭、生物膜形成或细胞因子诱导。文中讨论了细胞壁成分的活性，并描述了几种具有抗宿主细胞活性的输出型毒力因子。其他毒力因子使细菌能够在铁限制的环境中生长。
