Barisić Zvonimir, Babić-Erceg Andrea, Borzić Elmica, Zoranić Vinko, Kaliterna Vanja, Carev Merica
Department of Microbiology, Public Health Institute, Vukovarska 46, 21000, Split, Croatia.
Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:61-4. doi: 10.1016/s0924-8579(03)00233-4.
The aim of this study was to determine the distribution of uropathogens isolated from outpatients living in South Croatia and the in vitro susceptibility of these organisms to antimicrobial agents. Of 5080 enrolled uropathogen isolates, 82.28% isolates were Gram-negative, the most frequent isolates being Escherichia coli (62.62%), enterococci (10.18%), Proteus mirabilis (5.31%), Streptococcus agalactiae (3.84%), Staphylococcus spp. (3.70%), Pseudomonas spp. (3.46%), Klebsiella spp. (2.38%). The E. coli resistance rate was 42.17% to amoxycillin, 20.59% to trimethoprim-sulphamethoxazole and 6.09% to norfloxacin. Almost all Klebsiella spp. isolates were resistant to amoxycillin and the resistance rate to trimethoprim-sulphamethoxazole was over 20%, and 14.15% to the fluoroquinolones. A high methicillin-resistance rate was found among S. aureus (61.22%) and coagulase negative staphylococci (41.48).
本研究旨在确定从克罗地亚南部门诊患者中分离出的尿路病原体的分布情况，以及这些病原体对抗菌药物的体外敏感性。在5080株登记的尿路病原体分离株中，82.28%的分离株为革兰氏阴性菌，最常见的分离株为大肠埃希菌（62.62%）、肠球菌（10.18%）、奇异变形杆菌（5.31%）、无乳链球菌（3.84%）、葡萄球菌属（3.70%）、假单胞菌属（3.46%）、克雷伯菌属（2.38%）。大肠埃希菌对阿莫西林的耐药率为42.17%，对甲氧苄啶-磺胺甲恶唑的耐药率为20.59%，对诺氟沙星的耐药率为6.09%。几乎所有克雷伯菌属分离株对阿莫西林耐药，对甲氧苄啶-磺胺甲恶唑的耐药率超过20%，对氟喹诺酮类药物的耐药率为14.15%。金黄色葡萄球菌（61.22%）和凝固酶阴性葡萄球菌（41.48%）中发现了较高的耐甲氧西林率。
