核糖体与YidC。对大肠杆菌内膜蛋白生物合成的新见解。
The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins.
作者信息
de Gier Jan-Willem L, Luirink Joen
机构信息
Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE-106 91 Stockholm, Sweden.
出版信息
EMBO Rep. 2003 Oct;4(10):939-43. doi: 10.1038/sj.embor.embor921.
Abstract
In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly.
摘要
在大肠杆菌中，内膜蛋白（IMPs）通常通过信号识别颗粒途径靶向至Sec转位酶，Sec转位酶既能将蛋白质线性转运到周质中，也能将其侧向转运到脂质双层中。侧向转运似乎由内膜蛋白YidC协助。在本文中，我们讨论了最近的观察结果，这些结果表明核糖体在内膜蛋白靶向中起关键作用，以及YidC在内膜蛋白组装中的多种作用。
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