Weisstaub Adriana, Zeni Susana, de Ferrer Patricia, de Portela María Luz
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
Arch Latinoam Nutr. 2003 Jun;53(2):178-83.
The effect of dietary calcium (Ca) level on maternal zinc (Zn) nutritional status was studied. Female Wistar rats, weighing 250-350 g, were fed during pregnancy and lactation with an experimental diet containing/100 g different levels of calcium: 0.2 g (low calcium: LCa), 0.6 g (normal calcium: NCa) or 0.9 (high calcium: HCa). Maternal blood samples were drawn from the tail at delivery and at the end of lactation. Laboratory determinations were: Zn in whole blood (WB) at delivery and weaning; Zn (ZnF) and Ca (CaF) in the ashed femur at weaning. The results (mean +/- SEM) were: ZnWB (microgram/ml) at delivery and weaning: LCa: 8.73 +/- 1.05; 12.8 +/- 2.02; NCa: 3.49 +/- 0.19; 3.73 +/- 0.37; HCa: 3.21 +/- 0.19; 3.85 +/- 0.27. CaF (mg/100 mg): LCa: 19.2 +/- 0.8; NCa: 21.4 +/- 0.6; HCa: 20.4 +/- 1.1. ZnF (microgram/100 mg): LCa: 30.2 +/- 0.9; NCa: 24.1 +/- 0.3; HCa: 24.1 +/- 0.9. ZnWB was significantly higher in LCa (p < 0.0001) regarding NCa and Hca. ZnF showed an increase and CaF a decrease in LCa regarding NCa and HCa (p < 0.0001). There were no significant differences in ZnWB, ZnF and CaF between NCa and HCa These results show that: there was no detrimental effect when dietary Ca content was increased by 50% above the normal requirements of the rat.; low dietary Ca during pregnancy and lactation produced an increase of Zn utilization, reflected in maternal blood Zn and in ZnF content.
研究了膳食钙（Ca）水平对母体锌（Zn）营养状况的影响。选用体重250 - 350克的雌性Wistar大鼠，在其怀孕和哺乳期饲喂含不同钙水平（每100克）的实验日粮：0.2克（低钙：LCa）、0.6克（正常钙：NCa）或0.9克（高钙：HCa）。在分娩时和哺乳期结束时从大鼠尾部采集母体血样。实验室检测项目包括：分娩时和断奶时全血中的锌（WB）；断奶时灰化股骨中的锌（ZnF）和钙（CaF）。结果（均值±标准误）如下：分娩时和断奶时的ZnWB（微克/毫升）：LCa组分别为8.73±1.05；12.8±2.02；NCa组分别为3.49±0.19；3.73±0.37；HCa组分别为3.21±0.19；3.85±0.27。CaF（毫克/100毫克）：LCa组为19.2±0.8；NCa组为21.4±0.6；HCa组为20.4±1.1。ZnF（微克/100毫克）：LCa组为30.2±0.9；NCa组为24.1±0.3；HCa组为24.1±0.9。与NCa组和HCa组相比，LCa组的ZnWB显著更高（p < 0.0001）。与NCa组和HCa组相比，LCa组的ZnF升高而CaF降低（p < 0.0001）。NCa组和HCa组之间的ZnWB、ZnF和CaF无显著差异。这些结果表明：当膳食钙含量比大鼠正常需求量增加50%时，没有产生有害影响；怀孕和哺乳期低钙饮食使锌利用率增加，这反映在母体血液锌和ZnF含量上。
