Ding Meisong, Li Jinsheng, Deng Jun, Fourkal Eugene, Ma C M
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Med Phys. 2003 Sep;30(9):2520-9. doi: 10.1118/1.1603744.
This work investigates the dose correlation for deformed objects due to thoracic motion for radiotherapy treatment of breast cancer. An analytical model has been developed to reconstruct patient anatomy based on the assumption that the body will expand or compress proportionally during respiration. The patient geometry at any phase during a breathing pattern is reconstructed using the CT data taken at the inspiration and expiration phases and the breathing level which can be related to the measured chest wall motion. A correlation between the voxels in the inspiration (or expiration) geometry and the voxels in the reconstructed geometry at any phase of the breathing pattern is established so that the dose can be accumulated during a treatment. The method has been implemented for treatment planning dose calculation by interfacing with a Monte Carlo code. The patient geometry files for different phases of the breathing pattern are generated and the three-dimensional dose data are obtained from the Monte Carlo simulations. The final dose distribution is reconstructed from the dose data at different breathing phases based on patient's breathing pattern associated with chest wall movements.
这项工作研究了乳腺癌放射治疗中由于胸部运动导致的变形物体的剂量相关性。基于身体在呼吸过程中会按比例扩张或压缩的假设，开发了一种分析模型来重建患者解剖结构。使用在吸气和呼气阶段采集的CT数据以及与测量的胸壁运动相关的呼吸水平，重建呼吸模式中任何阶段的患者几何形状。建立吸气（或呼气）几何形状中的体素与呼吸模式任何阶段重建几何形状中的体素之间的相关性，以便在治疗过程中累积剂量。该方法已通过与蒙特卡罗代码接口实现用于治疗计划剂量计算。生成呼吸模式不同阶段的患者几何形状文件，并从蒙特卡罗模拟中获得三维剂量数据。根据与胸壁运动相关的患者呼吸模式，从不同呼吸阶段的剂量数据中重建最终剂量分布。
