Nakagawa Taneaki, Saito Atsushi, Hosaka Yasuo, Ishihara Kazuyuki
Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan.
Keio J Med. 2003 Sep;52(3):158-62. doi: 10.2302/kjm.52.158.
Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Arginine-specific gingipains (RgpA, RgpB) and lysine-specific gingipain (Kgp) have been studied for their ability to induce biologically significant antibodies. This review summarizes recent information on the gingipains and their possible application in the development of an anti-P. gingivalis vaccine.
牙龈卟啉单胞菌（P. gingivalis）是一种革兰氏阴性厌氧菌，与牙周病的发病机制有关，在牙周炎患者的龈下菌群中经常发现。这种微生物具有多种毒力因子，包括脂多糖、荚膜物质、菌毛和蛋白酶（酶）。在牙龈卟啉单胞菌抗原中，诸如精氨酸特异性牙龈蛋白酶（RgpA、RgpB）和赖氨酸特异性牙龈蛋白酶（Kgp）等酶因其诱导具有生物学意义抗体的能力而受到研究。本综述总结了关于牙龈蛋白酶及其在抗牙龈卟啉单胞菌疫苗开发中可能应用的最新信息。
