Caron Giulia, Ermondi Giuseppe
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via PGiuria 9, I-10125 Torino, Italy.
Mini Rev Med Chem. 2003 Dec;3(8):821-30. doi: 10.2174/1389557033487665.
This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.
