Broniszczak D, Kaminski A, Kalicinski P, Szymczak M, Ismail H, Drewniak T, Nachulewicz P, Markiewicz M, Teisseyre J
Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warsaw, Poland.
Transplant Proc. 2003 Sep;35(6):2271-2. doi: 10.1016/s0041-1345(03)00803-0.
An average of 15% of patients require retransplantation due to irreversible liver graft failure due to primary graft nonfunction, chronic rejection, vascular and biliary complications, or infections. The survival of patients and grafts after retransplantation is inferior to that after primary transplantation. The purpose of the present study was to examine the incidence, indications, and outcome of retransplantation in children. In our center 169 liver transplantations had been performed in 154 patients, and 14 patients (9%) required 15 retransplantations: nine in the early postoperative period, five late after primary transplantation, and one late after the second transplantation. One-year patient survival after primary transplantation was 82%, but after early retransplantation it was 55%.
平均15%的患者因原发性移植物无功能、慢性排斥反应、血管和胆道并发症或感染导致不可逆的肝移植失败而需要再次移植。再次移植后患者和移植物的存活率低于初次移植。本研究的目的是探讨儿童再次移植的发生率、适应证和结局。在我们中心,154例患者接受了169例肝移植,14例患者(9%)需要进行15次再次移植:9例在术后早期,5例在初次移植后期,1例在第二次移植后期。初次移植后1年患者生存率为82%,但早期再次移植后为55%。