通过呼吸相关动态PET减少肺癌PET成像中的呼吸运动伪影：方法及与呼吸门控PET的比较

Reduction of respiratory motion artifacts in PET imaging of lung cancer by respiratory correlated dynamic PET: methodology and comparison with respiratory gated PET.

作者信息

Nehmeh Sadek A, Erdi Yusuf E, Rosenzweig Kenneth E, Schoder Heiko, Larson Steve M, Squire Olivia D, Humm John L

机构信息

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

出版信息

J Nucl Med. 2003 Oct;44(10):1644-8.

PMID:14530480

Abstract

UNLABELLED

This study proposes a new method to reduce respiratory motion artifacts in PET images of lung cancer. The method is referred to as respiratory-correlated dynamic PET (RCDPET). RCDPET enables the acquisition of 4-dimensional PET data without the need for a respiratory tracking device. In this article, we compare this method with respiratory-gated PET (RGPET). Both methods provide the ability to correct for motion artifacts and more accurately quantitate radiotracer uptake within lung lesions. Both methods were evaluated in phantom studies and 1 patient.

METHODS

With RCDPET, data are acquired in consecutive 1-s time frames. A point source attached to a rigid foam block is set on the patient's abdomen and is extended into the camera field of view at the level of the lesion by means of a low-density rod. The position of this source is used to track respiratory motion through the consecutive dynamic frames. Image frames corresponding to a user-selected lesion position within the breathing cycle, in correlation with the point source position, are then identified after scanning. The sinograms of the selected image frames are summed and then reconstructed using iterative reconstruction with segmented attenuation correction.

RESULTS

The results from phantom studies with both RGPET and RCDPET were within 10% agreement, for both activity quantitation and image noise levels. In a clinical application, the quantitation of the SUV(max) and the lesion's size showed a 6% and 2% difference, respectively, between RCDPET and RGPET measurements.

CONCLUSION

RCDPET can be considered as a comparable, or alternative, method to RGPET in reducing the smearing effects due to respiration and improving quantitation of PET in the thorax. One advantage of RCDPET over RGPET is the ability to retrospectively reconstruct the PET data at any phase or amplitude in the breathing cycle.

摘要

未标注

本研究提出了一种减少肺癌PET图像中呼吸运动伪影的新方法。该方法被称为呼吸相关动态PET（RCDPET）。RCDPET能够在无需呼吸追踪设备的情况下采集四维PET数据。在本文中，我们将此方法与呼吸门控PET（RGPET）进行了比较。两种方法都具备校正运动伪影以及更准确地定量肺部病变内放射性示踪剂摄取的能力。两种方法均在体模研究和1例患者中进行了评估。

方法

使用RCDPET时，数据在连续的1秒时间帧内采集。将附着在刚性泡沫块上的点源放置在患者腹部，并通过低密度杆延伸至病变水平的相机视野内。该源的位置用于通过连续的动态帧追踪呼吸运动。扫描后，根据呼吸周期内用户选择的病变位置与点源位置的相关性，识别出相应的图像帧。将所选图像帧的正弦图相加，然后使用分段衰减校正的迭代重建进行重建。